PepAxis™-Sirius (formerly 686) is a high-reliability industrial-grade customized peptide synthesis system designed for large-scale industrial production. The system adopts a modular customized design, with reactor volumes ranging from 30 to 2000 L and synthesis scales of 0.3 mol and above, meeting the requirements of continuous and large-batch production.
The system is equipped with a double-jacketed temperature-controlled reactor, an amino acid activation tank, and a piperidine buffer tank, all featuring sight-glass designs for real-time monitoring of pressure, temperature, and stirring status, ensuring full-process controllability and traceability. It supports multi-solvent position management and precise quantitative transfer via metering pumps.
Combined with mechanical agitation and a wide temperature control range (–20 to 50 °C), the system effectively ensures process stability and reproducibility.
The system is certified for explosion protection and equipped with automatic alarm mechanisms, making it suitable for industrial-scale peptide drug production, process scale-up, and customized synthesis applications, providing customers with a safe, efficient, and scalable synthesis solution.
Q
What reactor volume range does the PepAxis™-Sirius system support?
The PepAxis™-Sirius system supports reactor volumes ranging from 30 L to 2000 L, making it suitable for both pilot-scale and full industrial-scale peptide synthesis production.
Q
What is the minimum synthesis scale supported by the PepAxis™-Sirius system?
The system supports synthesis scales of 0.3 mol and above, meeting the requirements for continuous and large-batch industrial peptide production.
Q
What materials are used for the reactor, amino acid activation tank, and deprotection buffer tank?
All three key vessels — the reactor, amino acid activation tank, and deprotection buffer tank — are constructed from 304 stainless steel with an inner lining of 316L stainless steel, ensuring excellent corrosion resistance and chemical compatibility for peptide synthesis processes.
Q
What temperature control range does the PepAxis™-Sirius system offer?
The system provides a wide temperature control range of –20 °C to 50 °C using water or ethylene glycol as the temperature control medium, ensuring process stability and reproducibility across various synthesis conditions.
Q
Is the PepAxis™-Sirius system certified for use in hazardous environments?
Yes. The PepAxis™-Sirius system is certified for explosion protection and is equipped with automatic alarm mechanisms, making it fully compliant for safe operation in industrial pharmaceutical manufacturing environments.
Q
What monitoring and control features does the PepAxis™-Sirius system provide?
The system features sight-glass designs on all major vessels for real-time monitoring of pressure, temperature, and stirring status. It also supports multi-solvent position management (up to 9 stations) and precise quantitative transfer via metering pumps, ensuring full-process controllability and traceability.