PepAxis™-Sirius (formerly 686) is a high-reliability industrial-grade customized peptide synthesis system designed for large-scale industrial production. The system adopts a modular customized design, with reactor volumes ranging from 30 to 2000 L and synthesis scales of 0.3 mol and above, meeting the requirements of continuous and large-batch production.
The system is equipped with a double-jacketed temperature-controlled reactor, an amino acid activation tank, and a piperidine buffer tank, all featuring sight-glass designs for real-time monitoring of pressure, temperature, and stirring status, ensuring full-process controllability and traceability. It supports multi-solvent position management and precise quantitative transfer via metering pumps.
Combined with mechanical agitation and a wide temperature control range (–20 to 50 °C), the system effectively ensures process stability and reproducibility.
The system is certified for explosion protection and equipped with automatic alarm mechanisms, making it suitable for industrial-scale peptide drug production, process scale-up, and customized synthesis applications, providing customers with a safe, efficient, and scalable synthesis solution.
Temperature Control Medium
Water / Ethylene Glycol
Solvent Stations
≤ 9
Reaction Vessel Material
304 Stainless Steel Lined with 316L Stainless Steel
Stirring Mode
Paddle Stirring
Amino Acid Activation Tank
304 Stainless Steel with 316L Stainless Steel Lining
Deprotection Buffer Tank
304 Stainless Steel with 316L Stainless Steel Lining
Explosion-Proof Rating / Power
220 / 380V
Frequently Asked Questions
Q
What reactor volume range does the PepAxis™-Sirius system support?
The PepAxis™-Sirius system supports reactor volumes ranging from 30 L to 2000 L, making it suitable for both pilot-scale and full industrial-scale peptide production with synthesis scales of 0.3 mol and above.
Q
What materials are used for the reactor and buffer tanks?
The reactor, amino acid activation tank, and deprotection buffer tank are all constructed from 304 stainless steel with 316L stainless steel lining, ensuring excellent chemical resistance and durability in demanding industrial environments.
Q
How does the PepAxis™-Sirius ensure process safety during large-scale production?
The system is certified for explosion protection and features automatic alarm mechanisms. Additionally, sight-glass designs on the reactor, amino acid activation tank, and piperidine buffer tank allow real-time monitoring of pressure, temperature, and stirring status throughout the synthesis process.
Q
What is the temperature control range of the system?
The PepAxis™-Sirius offers a wide temperature control range of –20 °C to 50 °C using water or ethylene glycol as the temperature control medium, delivered through a double-jacketed reactor design to ensure precise and stable thermal management.
Q
Is the PepAxis™-Sirius suitable for custom or non-standard synthesis applications?
Yes. The system adopts a modular customized design, making it highly adaptable for process scale-up, peptide drug production, and customized synthesis applications. Customers can configure the system to meet specific production requirements.
Q
How does the system manage solvent delivery and transfer accuracy?
The PepAxis™-Sirius supports up to 9 solvent stations and uses metering pumps for precise quantitative transfer of solvents and reagents, ensuring consistent dosing accuracy and reproducibility across large-scale production batches.