Peptide Applications

Today we are sharing a research article led by Zha Yuan's team, published in Analytical Chemistry. This study, through computationally biology-driven rational design, developed a novel Trop2-targeted peptide probe, [68Ga]Ga-NOTA-PEG2-WP8. It achieved, for the first time, non-invasive and dynamic Positron Emission Tomography (PET) imaging of Trop2 expression in triple-negative breast cancer (TNBC). It was also successfully applied for real-time monitoring of the treatment response to Trop2-targeted Antibody-Drug Conjugates (ADCs), providing a new molecular imaging tool for precision cancer diagnosis and therapy.

Today we share a study by Tobias Kronke et al., published in the Journal of Medicinal Chemistry. This research focuses on optimizing the structure of Nectin-4-targeting bicyclic peptides to develop 68Ga-labeled radioligands for tumor imaging. Through systematic structural modifications (such as bioisosteric replacement of methionine), the study not only improved the radiochemical purity and stability of the ligands but also validated their targeting efficacy for the first time in preclinical models and in a first-in-human application, providing a novel molecular tool for the precise diagnosis and treatment of Nectin-4-related cancers.

Today we are sharing a study led by Professor Oluf Pedersen from the University of Copenhagen, published in Nature Microbiology. This research, for the first time, discovered two novel peptides, RORDEP1 and RORDEP2, produced by the human gut commensal bacterium Ruminococcus torques(RT). These peptides are present in human circulation, show a negative correlation with obesity, and significantly improved glucose tolerance, increased bone density, and reduced fat accumulation in pre-clinical models. This provides new mechanistic insights and therapeutic potential for host metabolism regulation by microbially derived peptides.

Today we are sharing a research article led by Professors Rein V. Ulijn and Ye He from the Advanced Science Research Center at the City University of New York, published in Nature Materials, titled "Adaptive peptide dispersions enable drying-induced biomolecule encapsulation."

This article provides an overview of mainstream peptide-based skincare products, which are categorized into four types according to their functions and mechanisms: anti-wrinkle and firming, brightening and spot-fading, soothing and anti-irritation, and specialized treatments. It explains how these peptides interact with the skin at a molecular level and includes a detailed categorization and analysis of specific ingredient formulations available on the market.