Peptide Synthesis

To date, researchers have designed and developed over a hundred structurally diverse amide coupling reagents, significantly advancing the development of peptide synthesis. This article summarizes several commonly used coupling reagents in peptide synthesis.

Introduction to Fmoc Solid-Phase Synthesis

Fmoc solid-phase synthesis was pioneered by Eric Atherton and Bob Sheppard at the University of Cambridge in the late 1970s (systematically refined by Chan and White). Its core methodology employs the Fmoc (9-fluorenylmethoxycarbonyl) group as the α-amino protecting group for amino acids.